During mitosis, cells must spatiotemporally regulate gene expression programs to ensure accurate cellular division.Failures to properly regulate mitotic progression result in aneuploidy, a hallmark of cancer.Entry and exit from mitosis is largely controlled by waves of cyclin-dependent kinase (CDK) activity coupled to targeted protein degradation.T
Water-related conflicts: definitions, data, and trends from the water conflict chronology
Violence associated with freshwater resources has occurred throughout recorded history, with water triggering violence and armed conflict, water or water systems being used as weapons, and water or water systems becoming casualties during conflicts.Understanding the causes of water-related violence and regional and temporal trends is critical for i
Energy-Efficiency Improvement and Processing Performance Optimization of Forging Hydraulic Presses Based on an Energy-Saving Buffer System
This paper proposes an energy-saving Nail Care system based on a prefill system and a buffer system to improve the energy efficiency and the processing performance of hydraulic presses.Saving energy by integrating such systems into the cooling system of a hydraulic press has not been previously reported.A prefill system, powered by the power unit o